Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold

J Med Chem. 2000 Jun 15;43(12):2293-6. doi: 10.1021/jm0001368.
No abstract available

MeSH terms

  • Benzeneacetamides*
  • Collagenases / chemistry
  • Drug Design
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Matrix Metalloproteinase 13
  • Matrix Metalloproteinase Inhibitors*
  • Models, Molecular
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Pyrrolidinones / chemical synthesis*
  • Pyrrolidinones / chemistry
  • Structure-Activity Relationship

Substances

  • 3-(4-(4-fluorophenyloxy)phenyl)-2-oxopyrrolidine-4-hydroxamic acid
  • Benzeneacetamides
  • Hydroxamic Acids
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Pyrrolidinones
  • Collagenases
  • Matrix Metalloproteinase 13